Regenovue Deep Dermal Filler – 1ml

Patients want volume restored without looking restored. That pressure falls entirely on the filler sitting in the syringe. Regenovue Deep Dermal Filler is a CE-certified, fully cross-linked hyaluronic acid injectable gel from NeoGenesis Co., Ltd., and the reason clinics keep returning to it is not marketing; it is the structural behaviour of the gel itself. With 100% cross-linking, a documented 12 to 18-month duration of effect, and endotoxin levels sitting 99.2% below the European Pharmacopoeia limit, this is a filler built around what actually happens under the skin, not just on the surface of it.

What Is Regenovue Deep Dermal Filler?

Regenovue Deep is a monophasic high-viscosity HA gel indicated for medium to deep correction of the face. The HA content level is 24 mg/ml, produced from bacterial extraction of non-animal origin, eliminating animal contamination inherent in the old generation of dermal fillers.

There are two patented technologies which determine the behaviour of the gel after injection. The first, TLS (Ten Layers System), optimises the physical uniformity and viscoelasticity of the gel matrix during production. The second, SPLENDOR (Stable Property, Long-lasting Elasticity, Viscosity and Deformation on Reducing Temperature), manipulates molecular density by controlling the temperature in order to create a matrix that has a shape and does not something that will melt uncontrollably. As a result of the technology used in its production, the gel has increased elasticity by 45% and higher viscosity by 31% compared to other products manufactured by the same companies; the elasticity helps ensure that the Regenovue filler moves along with the facial muscles, while viscosity ensures that the filler does not migrate into the nearby tissues.

The remaining amount of crosslinker (BDDE) is not found in the product, and endotoxins are controlled at a concentration below 0.0015 IU/mg.s

What Regenovue Deep Is Used For?

Injection depth is that of the lower dermis and upper subcutaneous fat layer, thereby making this Regenovue filler suitable for structural augmentation, not superficial augmentation. It is administered wherever there is a need for volume restoration, deep lines that cannot be addressed by topical products, or when there is a requirement for reshaping of the face. Areas of administration include:

• Nasolabial folds
• Lip augmentation and border definition
• Cheek volumisation and age-related volume restoration
• Marionette lines
• Chin and jawline contouring
• Non-surgical nasal augmentation (liquid rhinoplasty)
• Moderate forehead lines
• Perioral lines

Each pack includes one prefilled syringe along with two sterile needles of 27G size. For clinics which have to handle the entire process of facial correction, Regenovue Deep is positioned between Regenovue Fine which is used for surface applications and Regenovue Sub-Q which is used for deep subcutaneous correction and provides the clinician with a cohesive series of CE-marked products for all injection depths.

Regenovue Deep vs. Regenovue Deep Plus: The Difference in Practice

The composition is the same in both cases. In addition to 24 mg/ml of hyaluronic acid, Regenovue Deep Plus incorporates 3mg/ml of lidocaine phosphate. Anaesthesia is incorporated in the syringe instead of being applied externally. Most of the time, the Plus version will be preferred over the former. The standard Regenovue Deep without lidocaine is reserved for patients with a documented sensitivity to local anaesthetics.

Composition And Its Main Advantages

The Regenovue Deep consists of crosslinked hyaluronic acid with a concentration of 24mg/ml, phosphate-buffered saline as a carrier and Lidocaine for the Plus formulation. The fact that the product is monophasic implies that it is a homogeneous mixture without any clusters of particles. This is very important because it helps to avoid non-uniform distribution during application.

No Migration After Injection

The 100% cross-linked structure anchors the gel at the injection site. During clinical assessment, no filler migration was recorded across test applications. For areas adjacent to delicate structures, particularly the periorbital region or the nasolabial fold near the nose, staying in place is not a minor feature.

Results That Last

The period of 12 to 18 months is the period of effectiveness of the HA network and not the best-case scenario. The longevity of effectiveness depends on the area of application, metabolism of the patient, and amount injected; however, the period is relatively comparable to CE-registered products.

Patient Comfort by Design

The Plus variant’s integrated lidocaine removes a procedural step and measurably reduces injection discomfort, which matters most in high-sensitivity areas. That is not an add-on feature; it is built into the formulation at 3mg/ml, calibrated to anaesthetise without interfering with the gel’s physical properties.

Who Can Purchase Regenovue Deep in the UK?

Supply of Regenovue Deep is restricted to licensed practitioners and qualified clinic accounts. The UK regulatory environment around dermal fillers has been tightening steadily, and practitioners need to understand where things currently stand.

Facial dermal fillers sit within the amber tier of the government’s three-tier licensing model, published in the August 2025 consultation response from the Department of Health and Social Care. Amber-tier treatments can be administered independently by qualified healthcare professionals, while non-healthcare practitioners require oversight from a named, regulated healthcare professional.

The MHRA has also confirmed plans to formally bring aesthetic dermal fillers within the scope of UK Medical Device Regulations, introducing stricter supply chain traceability and post-market surveillance requirements. The House of Commons Library briefing is tracking these developments.

Regenovue Deep is provided to qualified users by Vibe Pharma which is a pharmacy registered with the GPhC in the United Kingdom and based in Salford. Vibe Pharma conducts verification of credentials before the order is delivered in order to ensure that procurement remains consistent with MHRA guidelines. Practitioners looking to open a professional account are welcome to get in touch directly through the Vibe Pharma website at vibepharma.co.uk.

Eligible purchasers typically include:

• Licensed medical professionals with aesthetic prescribing or procurement authority.
• Registered aesthetic clinics purchasing for qualified professional use.
• Wholesale buyers with valid business credentials and compliant resale arrangements.

Who Should Not Receive This Treatment?

Patient selection is the treating practitioner’s responsibility. Regenovue Deep should not be used where:

• Known hypersensitivity to hyaluronic acid or any formulation component is present.
• Active infection exists at the intended injection site.
• The patient is pregnant or breastfeeding.
• Bleeding disorders or recent facial surgery are factors.
• Lidocaine sensitivity is documented (relevant to the Plus variant; switch to standard Regenovue Deep in these cases).

Informed consent and a thorough pre-treatment assessment should be standard protocol before any session proceeds.

Storage and Handling

Regenovue Deep must be stored at 2°C to 25°C. Freezing and direct sunlight exposure both compromise the gel’s structural integrity. Shelf life is 24 months from the manufacture date. On receipt, check batch numbers and expiry dates, store in original packaging until point of use, and rotate stock by expiry date. For multi-site clinics or distributor accounts, documented batch traceability is especially important given the direction of MHRA post-market surveillance requirements.